Start by defining too much leading. It is possible in some circumstances to get little or no leading, but generally some leading is normal with cast bullets. It is a matter of how much and how easy to clean. My personal rule of thumb is that you should be able to fire at least 200 rounds and preferably 400 before leading is heavy enough to need cleaning before continuing shooting. Maybe you are getting worried too soon.
Having said that let me offer the following. Sizing to 452 is right for a 4515 groove. Lee liquid alox works well in some guns but not others. I have noticed no particular pattern so I have no idea how to determine that in advance. I don't like it for cosmetic reasons, but more importantly, I have encountered no significant leading with conventional canelure lubricants. Some lubes may be better than others, and as others have said, in some cases a particular leading problem has been cured by a particular lube. In general, though, I have used 50/50 Alox/beeswax and various hard wax lubes and all have been OK. At 45ACP velocities any decent lube should be OK. I therefore recommend you try a conventional canelure bullet with any good lube.
You don't need particularly hard bullets for 45ACP, so water quenching is waste of time. But more than that, note that it works only if the alloy contains a particular percentage of arsenic. Furthermore, tin inhibits the quenching effect, so the aloy needs a minima percentage of tin. Traditionally, wheelweights were formulated with exactly the right composition to harden successfully with water quenching. There is no guarantee they are that composition these days, and I have noticed that they are consistently softer than they should be.
They should contain 4% antimony but often contain only 2 or 3%. I am aware that wheelweights are popularly used as is in the US, but that is below the cast bullet industry standard of 6%, and I would not risk less than 6% for customers who might be firing them in long barrelled 357 or 44 Mag revolvers. 45ACP velocity is more tolerant and you will often gt away with WW, but my advice is to add 3% antimony to your next melt.
Antimonial alloys age harden over about three weeks, so don't shoot them soon after they are cast. To summarise, use a conventional cnelure lubed bullet with a good lube, cast with 6% antimony, size to 452, and I will be surprised if it does not work.
Dicko